VDR is a gene which encodes a vitamin D receptor protein. This protein regulates calcium absorption and bone development. A variant of the gene (rs2228570 FokI polymorphism) is associated with reduced bone mineral density among white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern as well as the temporal occupancy of the VDRE between the two components. It is also modulated by chromosomal position and binding preferences for certain hormones. Microarray studies of human cells have https://www.gescheftmarketing.de/2021/12/29/gaining-knowledge-and-business-direction/ revealed that more than 100 genes are enriched with VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) is an archive of data and documents that are relevant to business, legal transactions or other processes. Viewing, downloading, and printing are all restricted. It is accessed via a central computer as well as an extranet, which is a restricted-access Internet connection, allowing users to log on at set times.
Companies and investment banks that are involved in mergers and acquisitions are the most frequent users of VDRs. VDR. They require an efficient and secure platform to share information with investors or buyers in a way that is transparent, and due diligence can require massive amounts of data. Life science companies also make use of VDRs for everything from clinical trial results to HIPAA compliance documents.